|
KMID : 0043320130360050626
|
|
Archives of Pharmacal Research
2013 Volume.36 No. 5 p.626 ~ p.633
|
|
|
Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats
|
|
Shin Dong-Su
Kim Kung-Wook
Chung Hae-Young
Yoon Sik
Moon Jeon-Ok
|
|
|
Abstract
|
|
|
|
Acute hepatic inflammation is regarded as a hallmark of early stage fibrosis, which can progress to extensive fibrosis and cirrhosis. Sinapic acid is a phenylpropanoid compound that is abundant in cereals, nuts, oil seeds, and berries and has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the anti-inflammatory effect of sinapic acid in carbon tetrachloride (CCl4)-induced acute hepatic injury in rats. Sinapic acid was administered orally (10 or 20 mg/kg) to rats at 30 min and 16 h before CCl4 intoxication. Sinapic acid treatment of rats reduced CCl4-induced abnormalities in liver histology, serum alanine transaminase and aspartate transaminase activities, and liver malondialdehyde levels. In addition, sinapic acid treatment significantly attenuated the CCl4-induced production of inflammatory mediators, including tumor necrosis factor-alpha and interleukin-1β mRNA levels, and increased the expression of nuclear factor-kappa B (NF-κB p65). Sinapic acid exhibited strong free radical scavenging activity in vitro. Thus, sinapic acid protected the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinapic acid may thus have potential as a therapeutic agent for suppressing hepatic inflammation.
|
|
|
KEYWORD
|
|
|
Sinapic acid, Hepatoprotective effect, Antifibrogenic effect, Antioxidant effect, Liver fibrosis, Hepatic stellate cell, NF-κB p65, TNF-α, IL-1β
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|